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sulfacetamide sodium and sulfur Sodium Sulfacetamide - Sulfur

Generic: sulfacetamide sodium and sulfur

Verified·Apr 23, 2026
Manufacturer
Mission Pharmacal
NDC
28595-501
RxCUI
2531383
Route
TOPICAL
ICD-10 indication
L70.0

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About sulfacetamide sodium and sulfur Sodium Sulfacetamide - Sulfur

What is this medication? Sulfacetamide sodium and sulfur is a topical prescription medication used primarily to treat various inflammatory skin conditions. It is commonly prescribed for the management of acne vulgaris, acne rosacea, and seborrheic dermatitis, which is a condition characterized by scaly or flaky skin. This combination product works by targeting the underlying causes of these skin issues, helping to reduce redness, inflammation, and the formation of blemishes or crusting on the surface of the skin. The medication combines two active ingredients that perform different functions to improve skin health. Sulfacetamide sodium is a sulfonamide antibiotic that stops the growth of certain bacteria that contribute to acne and skin infections. Sulfur acts as a keratolytic agent, which helps to soften and shed dead skin cells while drying up excess oil. Together, these components help clear up existing lesions and prevent new ones from forming, making it an effective treatment for patients who have not responded to over-the-counter options.

Copay & patient assistance

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Prescribing information

From the FDA-approved label for sulfacetamide sodium and sulfur Sodium Sulfacetamide - Sulfur. Official source: DailyMed (NLM) · Label effective Feb 11, 2026

Indications and usage
INDICATIONS Sodium Sulfacetamide 9% - Sulfur 4.25% Suspension is indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.
Dosage and administration
DOSAGE AND ADMINISTRATION SHAKE WELL before use. Cleanse affected areas. Apply Sodium Sulfacetamide 9% - Sulfer 4.25% Suspension once or twice daily to affected areas, or as directed by your physician. Wet skin and liberally apply to areas to be cleansed. Massage gently into skin for 10-20 seconds, working into a full lather, rinse thoroughly and pat dry. If skin dryness occurs, it may be controlled by rinsing off Sodium Sulfacetamide 9% - Sulfer 4.25% sooner or using less often.
Contraindications
CONTRAINDICATIONS Sodium Sulfacetamide 9% - Sulfer 4.25% Supesnion is contraindicated for use by patients having known hypersensitivity to sulfonamides, sulfur or any other component of this preparation. Sodium Sulfacetamide 9% - Sulder 4.25% Supension is not to be used by patients with kidney disease.
Warnings
WARNINGS Although rare, sensitivity to sodium sulfacetamide may occur. Therefore, caution and careful supervision should be observed when prescribing this drug for patients who may be prone to hypersensitivity to topical sulfonamides. Systemic toxic reactions such as agranulocytosis, acute hemolytic anemia, purpura hemorrhagica, drug fever, jaundice and contact dermatitis indicate hypersensitivity to sulfonamides. Particular caution should be employed if areas of denuded or abraded skin are involved. Sulfonamides are known to cause Stevens-Johnson syndrome in hypersensitive individuals. Stevens-Johnson syndrome also has been reported following the use of sodium sulfacetamide topically. Cases of drug-induced systemic lupus erythematosus from topical sulfacetamide also have been reported. In one of these cases, there was a fatal outcome. FOR EXTERNAL USE ONLY. NOT FOR OPHTHALMIC USE. Avoid contact with eyes, lips and mucous membranes. KEEP OUT OF REACH OF CHILDREN. Keep container tightly closed.
Drug interactions
Drug Interactions This product is incompatible with silver preparations.
Adverse reactions
ADVERSE REACTIONS Reports of irritation and hypersensitivity to sodium sulfacetamide are uncommon. The following adverse reactions, reported after administration of sterile ophthalmic sodium sulfacetamide, are noteworthy: instances of Stevens-Johnson syndrome and instances of local hypersensitivity which progressed to a syndrome resembling systemic lupus erythematosus; in one case a fatal outcome was reported (see WARNINGS ). Call your doctor for medical advice about side effects. To report SUSPECTED ADVERSE REACTIONS or obtain product information, contact Allegis Pharmacuticals, LLC at 1-866-633-9033 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Use in pregnancy
PREGNANCY Category C Animal reproduction studies have not been conducted with Sodium Sulfacetamide 9% - Sulfer 4.25% Suspension. It is not known whether Sodium Sulfacetamide 9% - Sulfer 4.25% Suspension can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sodium Silfacetamide 9% - Sulfer 4.25% should be given to a pregnant woman only if clearly needed or when potential benefits outweigh potential hazards to the fetus.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.