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Efudex

Generic: Fluorouracil

Verified·Apr 23, 2026
Manufacturer
Bausch Health
NDC
0187-3204
RxCUI
105583
Route
TOPICAL
ICD-10 indication
L57.0

Affordability Check

How much will you actually pay for Efudex?

In 30 seconds, see every legitimate way to afford Efudex — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.

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About Efudex

What is this medication? Efudex is a topical prescription cream that contains the active ingredient fluorouracil, which belongs to a class of medications known as antimetabolites. It is most commonly used to treat actinic or solar keratoses, which are rough, scaly patches on the skin caused by years of sun exposure. These growths are considered precancerous, and treating them with this medication helps to eliminate abnormal cells before they have the chance to develop into more serious forms of skin cancer.

The medication is also utilized for the treatment of a specific type of skin cancer known as superficial basal cell carcinoma when other surgical methods are not ideal. It works by blocking the growth of rapidly dividing cells, specifically targeting the abnormal ones while sparing healthy tissue to a greater extent. During the course of treatment, the skin typically becomes red, irritated, and crusty as the medication clears away the damaged cells to allow for the growth of healthy new skin.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

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Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Medicare Part D coverage

How Efudex appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-04-30).

Covered by plans

60%

3,319 of 5,509 plans

Most common tier

Tier 2

On 33% of covering formularies

Prior authorization required

0%

of covering formularies

TierFormularies on this tierShare
Tier 1 (preferred generic)65
20%
Tier 2 (generic)109
33%
Tier 3 (preferred brand)50
15%
Tier 4 (non-preferred brand)105
32%

Step therapy: 0% of formularies

Quantity limits: 61% of formularies

Coverage breadth: 329 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

PayerPAStep therapyCopay tier

Medicare Part D

Related drugs

How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.